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(Rac)-JBJ-04-125-02
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产品介绍
产品介绍
产品信息
抗原名称
EGFR:0.26 nM
商品描述
JBJ-04-125-02 is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.
分子量
543.6
纯度
96%
可溶性
DMSO:55 mg/mL (101.17 mM)
In vitro(体外研究)
(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1].
In vivo(体内研究)
The combination of osimertinib and JBJ-04-125-02 is a significantly more effective treatment approach than either agent alone[1].
背景
分子式
C29H26FN5O3S
CAS号
2140807-05-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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