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产品介绍
产品信息
荧光素标记
抗原名称
RALY
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro163 of human RALY protein. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
38
研究领域
RNA 调节与翻译调控
应用
反应种属
Human,Monkey,
目标/特异性
Specificity/Sensitivity
RALY Antibody recognizes endogenous levels of total RALY protein.
Species Reactivity:
Human, Monkey
敏感性
Endogenous
背景
背景
RALY is a member of the large family of heterogeneous nuclear ribonucleoproteins (hnRNPs). RALY was initially discovered in lethal yellow mice, a condition where heterozygotes display an all yellow coat, obesity, diabetes, and tumors. In this condition, mRNA to the 5’ untranslated region of RALY fuses to the agouti transcript (1,2). RALY binds to U-rich elements in coding and non-coding mRNAs undergoing translation (3). RALY has been implicated in certain cancer types, as it can control transcriptional regulation and splicing of E2F1 and PRMT1 mRNAs (4,5).
1.Michaud, E.J. et al. (1994) Proc Natl Acad Sci U S A 91, 2562-6.
2.Michaud, E.J. et al. (1993) Genes Dev 7, 1203-13.
3.Rossi, A. et al. (2017) Nucleic Acids Res 45, 6775-6792.
4.Bondy-Chorney, E. et al. (2017) Int J Biochem Cell Biol 91, 124-135.
5.Cornella, N. et al. (2017) J Biol Chem 292, 19674-19692.
研究领域
RNA 调节与翻译调控
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
22913
UniProt ID
Q9UKM9
参考图片
Western blot analysis of extracts from various cell lines using RALY Antibody.
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