Recombinant Mouse CTLA-4 Protein(C-10His)

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Recombinant Mouse CTLA-4 Protein(C-10His)

品牌： Absin

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分子量：

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产品介绍

产品信息

序列号

Protein sequence (P09793, Glu36-Asp161, with C-10*His) EAIQVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQGLRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDGGGGSHHHHHHHHHH

分子量

Detects a band of approximately : 20-30 kDa(Predicted molecular weight: 15.6 kDa)

纯度

＞95% by SDS-PAGE

外观

Lyophilized Powder

表达系统

HEK cells

标签

His Tag

背景

CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. The CTLA-4 protein is encoded by the Ctla-4 gene in mice and the CTLA-4 gene in humans.

制备和贮存

保存方式

Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

参考图片

2ug（R: reducing conditions）

Immobilized Recombinant Mouse B7-1 (C-Fc) at 4ug/mL (50 uL/well) can bind Mouse CD152, his tag with EC50 of 16.27-21.58 ng/mL.

2ug（R: reducing conditions）

Immobilized Recombinant Mouse B7-1 (C-Fc) at 4ug/mL (50 uL/well) can bind Mouse CD152, his tag with EC50 of 16.27-21.58 ng/mL.

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货号：

abs06398-1mg

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