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产品介绍
产品信息
商品描述
Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.
分子量
376.5
纯度
≥95%
可溶性
Soluble in water (0.05 mg/mL) at 25° C, PBS pH 7.2 (~0.05 mg/mL), DMSO (~50 mg/mL), DMF (~50 mg/mL), and ethanol.
浓度
100ug/ml
外观
solution in ethanol
IC50
polymorphonuclear leukocyte (PMNL) transendothelial migration: EC5050 = ~30 nM (human)
应用
实验应用
An anti-inflammatory that reduces human polymorphonuclear leukocyte transendothelial migration
背景
分子式
C22H32O5
CAS号
872993-05-0
沸点
78° C
制备和贮存
保存方式
Store at -80° C，1 year.
参考图片
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