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RG2833
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产品介绍
产品介绍
产品信息
抗原名称
HDAC3 ,HDAC1
商品描述
RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
分子量
339.43
纯度
>98%
可溶性
DMSO 68 mg/mL (200.33 mM)
Ethanol 10 mg/mL (29.46 mM)
Ethanol 10 mg/mL (29.46 mM)
外观
Powder
In vitro(体外研究)
RGFP109 dose-dependently upregulates frataxin mRNA and protein levels in cultures of unstimulated peripheral blood mononuclear cells (PBMC) obtained from FRDA patients.
In vivo(体内研究)
RG2833 (150 mg/kg) corrects frataxin deficiency and increases histone acetylation in the brain and heart of KIKI mice without acute toxicity signs. RGFP109 ameliorates the disease phenotype of a Friedreich ataxia mouse model. RGFP109 (30 mg/kg p.o.) also alleviates established l-DOPA-induced dyskinesia.
背景
别名
RG 2833, RG FP109, RG-2833, RGFP-109
分子式
C20H25N3O2
CAS号
1215493-56-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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