RS 504393 (10 mg)

9953769

Highly selective CCR2 chemokine receptor antagonist

417.5

6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Extremely selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.

≥99% (HPLC)

Soluble to 10 mM in DMSO

CC1=C(CCN2CCC3(CC2)OC(=O)NC2=C3C=C(C)C=C2)N=C(O1)C1=CC=CC=C1

C₂₅H₂₇N₃O₃

300816-15-3