SAG (1 mg)

5284330

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

490.06

3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

Potent Smoothened (Smo) receptor agonist (K_d = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC₅₀ ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl

ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12

C₂₈H₂₈ClN₃OS

912545-86-9