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产品介绍
产品介绍
产品信息
抗原名称
eIF-2α phosphatase
商品描述
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
分子量
463.21
纯度
>98%
可溶性
DMSO ：46.3 mg/mL (100 mM)
外观
白色或类白色粉末
In vitro(体外研究)
Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB).
In vivo(体内研究)
Sal003 impairs spatial long-term memory formation in rats.
背景
别名
SAL003；(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide
分子式
C18H15Cl4N3OS
CAS号
1164470-53-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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