Salmeterol-d3 (xinafoate)

An internal standard for the quantification of salmeterol

Salmeterol-d3 is intended for use as an internal standard for the quantification of salmeterol (Item No. 16009) by GC- or LC-MS. Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively).1 It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM.1,2 Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.3 Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.

606.8

≥99% deuterated forms (d1-d3)

GR-33343G-d3

OC([2H])([2H])C1=CC(C(O)([2H])CNCCCCCCOCCCCC2=CC=CC=C2)=CC=C1O.OC3=C(C(O)=O)C=CC4=CC=CC=C43

C25H34D3NO4 • C11H8O3

≥ 4 years

DMF: 30 mg/ml DMSO: 25 mg/ml Ethanol: 2 mg/ml