SB 224289 hydrochloride (10 mg)

11226716

Selective 5-HT_1B antagonist

557.09

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride

Selective 5-HT_1B receptor antagonist (pK_i = 8.2). Displays > 60-fold selectivity over 5-HT_1D, 5-HT_1A, 5-HT_1E, 5-HT_1F, 5-HT_2A and 5-HT_2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.

≥95% (HPLC)

Soluble to 10 mM in DMSO with gentle warming

O=C(C5=CC=C(C6=CC=C(C7=NOC(C)=N7)C=C6C)C=C5)N2C1=CC3=C(OCC43CCN(CC4)C)C=C1CC2.Cl

C₃₂H₃₂N₄O₃.HCl

180084-26-8