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产品介绍
产品介绍
产品信息
商品描述
SC-236 is a highly selective and potent inhibitor of Cox-2 (IC50 of 10 nM) which also inhibits Cox-1 (IC50 of 17.8 μM) and has antitumor properties. SC-236 exhibits longer half-life time and reduced gastric toxicity in the fasting rat model. SC-236 has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. SC-236 exhibits a potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.
分子量
401.8
纯度
98%
可溶性
Soluble in DMSO (> 20 mg/ml), methanol, and ethanol (100 mM).
外观
white to off-white crystalline powder
IC50
COX-2: IC50 = 0.45 nM (human); COX-1: IC50 = 17.8 µM (human)
背景
别名
SC 236；SC58236
分子式
C16H11ClF3N3O2S
CAS号
170569-86-5
沸点
543.41° C at 760 mmHg (Predicted)
MDL
MFCD00941297
PK值
pKa: 9.66
密度
1.54 g/cm3 (Predicted)
折射率
n20D 1.63 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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