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产品介绍
产品信息
荧光素标记
抗原名称
SGLT2
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SGLT2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
分子量
46-75
研究领域
神经科学
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
SGLT2 Antibody recognizes endogenous levels of total SGLT2 protein. This antibody does not recognize SGLT1 protein.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
Na(+)/glucose cotransporter 2 (SGLT2) is one of the two main glucose transporters in the kidney proximal convoluted tubule. It is activated by Protein Kinase A and Protein Kinase C, likely through phosphorylation of Ser624 (1,2). SGLT2 is responsible for the majority of glucose reabsorption in the kidney (3,4), and mutations in SGLT2 are known to cause familial renal glucosuria (5,6). SGLT2 is a therapeutic target for type 2 diabetes. Inhibitors of SGLT2 have been developed in order to treat people with type 2 diabetes (7).
1.Feric, M. et al. (2011) Am J Physiol Cell Physiol 300, C755-70.
2.Ghezzi, C. and Wright, E.M. (2012) Am J Physiol Cell Physiol 303, C348-54.
3.Wells, R.G. et al. (1992) Am J Physiol 263, F459-65.
4.Wright, E.M. (2001) Am J Physiol Renal Physiol 280, F10-8.
5.Lee, H. et al. (2012) Pediatr Nephrol 27, 1091-5.
6.Andrianesis, V. and Doupis, J. (2013) Expert Rev Clin Pharmacol 6, 519-39.
7.Sheridan, C. (2012) Nat Biotechnol 30, 899-900.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
6524
UniProt ID
P31639
参考图片
Immunoprecipitation of SGLT2 from human kidney membrane extracts using Normal Rabbit IgG #2729 (lane 2) or SGLT2 Antibody (lane 3). Lane 1 is 10% input. Western blot analysis was performed using SGLT2 Antibody.
Western blot analysis of extacts from human kidney membrane fraction lysates, untreated (-) or treated with PNGase F (+), using SGLT2 Antibody.
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