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产品信息
宿主
鼠
克隆号
73.3
研究领域
免疫学和肿瘤学,癌症
Product Details
The 73.3 monoclonal antibody reacts with mouse fibroblast activation protein (FAP), a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is expressed during embryonic development, in tissues of healing wounds, and in chronic inflammatory and fibrotic conditions. FAP expression is highly upregulated in cancer-associated fibroblasts in epithelial tumors. Cancer-associated fibroblasts overexpression of FAP promotes tumor development and metastasis by influencing extracellular matrix remodeling, intracellular signaling, angiogenesis, epithelial-to-mesenchymal transition, and immunosuppression. The scFv of the 73.3 antibody has been used to construct 73.3-FAP-CAR T cells specific for FAP. Adoptively transferred 73.3-FAP-CAR T cells have been shown to inhibit the growth of multiple syngeneic mouse tumor models. Note: The 73.3 monoclonal antibody does not cross-react with human FAP (refer to Wang et. al., 2014 for more details).Specifications
| Isotype | Mouse IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb mouse IgG1 isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Mouse FAP-expressing 3T3 cells |
| Reported Applications | Chimeric antigen receptor construction Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Purification | Protein G |
| RRID | AB_2927511 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
应用
反应种属
Mouse
背景
研究领域
Cancer Biology, Immunology, Tumor Antigens
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