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Sertraline hydrochloride
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产品介绍
产品介绍
产品信息
抗原名称
5-HT
商品描述
Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM.
分子量
342.69
纯度
>98%
可溶性
DMSO ：34.3 mg/mL (100 mM)
Water ：1.7 mg/mL (5 mM)
Water ：1.7 mg/mL (5 mM)
外观
白色或类白色结晶性粉末
In vitro(体外研究)
Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents.
In vivo(体内研究)
Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of dihydroalprenolol to cortical membranes.
背景
别名
盐酸舍曲林
分子式
C17H17Cl2N.HCl
CAS号
79559-97-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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