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SET07 (Histone H4-K20 Methyltransferase, H4-K20-HMTase, SET Domain-containing Protein 8, PR/SET Domain-containing Protein 07, PR/SET07, PR-Set7, KMT5A
品牌： MyBioSource
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对比
咨询反应种属：
Human
实验应用：
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by Protein G affinity chromatography.
抗原名称
SETD8 protein
免疫原
Recombinant corresponding to human SET7/9 protein.
商品描述
SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.
克隆号
S4E5
形式
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
产品类型
Monoclonal
应用
实验应用
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
反应种属
Human
背景
别名
Anti -SET07 (Histone H4-K20 Methyltransferase, H4-K20-HMTase, SET Domain-containing Protein 8, PR/SET Domain-containing Protein 07, PR/SET07, PR-Set7, KMT5A, Histone-lysine N-methyltransferase SETD8, H4-K20-HMTase SETD8, Lysine N-methyltransferase 5A, PRSET7, S
制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
NCBI
387893
UniProt ID
Q9NQR1
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