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Setmelanotide

产品介绍
产品介绍
产品信息
序列号
Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond: Cys2-Cys8)

商品描述
Setmelanotide (RM-493;BIM-22493;IRC-022493) is a melanocortin 4 receptor (MC4R) agonist with an EC50 of 0.27 nM for human MC4R.

分子量
1117.31

纯度
98%

可溶性
DMSO : 100 mg/mL (89.50 mM),

In vitro(体外研究)
Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively.

In vivo(体内研究)
Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively.

来源(爱必信)
Synthetic

背景
别名
司美诺肽

分子式
C49H68N18O9S2

CAS号
920014-72-8

制备和贮存
保存方式
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
参考图片
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