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产品介绍
产品介绍
产品信息
抗原名称
PTEN
商品描述
SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。
分子量
307.34
纯度
＞98%
可溶性
DMSO ：30.7 mg/mL (100 mM)
外观
Red-violet solid
In vitro(体外研究)
SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions.
In vivo(体内研究)
Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia.
背景
分子式
C19H17NO3
CAS号
345630-40-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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