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产品介绍
产品介绍
产品信息
商品描述
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK.
分子量
389.24
纯度
98%
可溶性
DMSO ：78 mg/mL (200.39 mM)
Ethanol ：39 mg/mL (100.20 mM)
Ethanol ：39 mg/mL (100.20 mM)
外观
white to beige powder
In vitro(体外研究)
SGC-GAK-1 potently binds cyclin G-associated kinase (GAK), adaptor protein 2-associated kinase (AAK1), serine/threonine kinase 16 (STK16) with Kis of 3.1 nM, 53 µM, 51 µM, respectively.SGC-GAK-1 potently binds cyclin G-associated kinase (GAK), receptor-interacting protein kinase 2 (RIPK2), AarF domain containing kinase 3 (ADCK3), and nemo-like kinase (NLK) with KDs of 1.9 nM, 110 nM, 190 nM, and 520 nM, respectively.SGCGAK-1 (0.1, 1, and 10 µM, 48 hours or 72 hours) shows strong growth inhibition in LNCaP, VCaP, and 22Rv1 cells at 10 µM, but minimal effect in PC3 and DU145 cells.Cell Viability AssayCell Line:Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145) Concentration:0.1, 1, and 10 µMIncubation Time:48 hours or 72 hoursResult:Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 µM and 0.17±0.65 µM, respectively.
背景
分子式
C18H17BrN2O3
CAS号
2226517-76-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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