SGX 523 (10 mg)

24779724

Selective and potent c-MET kinase inhibitor

359.41

6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline

Potent and selective c-MET kinase inhibitor (IC₅₀ = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

≥99% (HPLC)

Soluble to 20 mM in DMSO

CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

C₁₈H₁₃N₇S

1022150-57-7