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产品介绍
产品介绍
产品信息
荧光素标记
来源纯化
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human SHANK2 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
同种型
Rabbit IgG
分子量
165
应用
目标/特异性
Specificity/Sensitivity
SHANK2 (D1N4C) Rabbit mAb recognizes endogenous levels of total SHANK2 protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
The SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD) (1), where they play a critical role in PSD assembly of excitatory synapses during development (2). While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer (3), proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins (4). At the synapse, SHANK proteins interact with NMDA receptors and metabotropic glutamate receptor complexes (5). Research studies have proposed the involvement of SHANK proteins in autism and neurodegenerative diseases (1).
1.Grabrucker, A.M. et al. (2011) Trends Cell Biol 21, 594-603.
2.Boeckers, T.M. et al. (1999) J Neurosci 19, 6506-18.
3.Boeckers, T.M. et al. (2005) J Neurochem 92, 519-24.
4.Sala, C. et al. (2001) Neuron 31, 115-30.
5.Boeckers, T.M. et al. (2002) J Neurochem 81, 903-10.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
22941
UniProt ID
Q9UPX8-4
参考图片
Western blot analysis of extracts from various tissues using SHANK2 (D1N4C) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
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