Snail (SN9H2) Rat mAb

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10). 1.Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151-3161. 2.Cano, A. et al. (2000) Nat. Cell Biol. 2, 76-83. 3.Batlle, E. et al. (2000) Nat. Cell Biol. 2, 84-89. 4.Yokoyama, K. et al. (2003) Int. J. Oncol. 22, 891-898. 5.Yokoyama, K. et al. (2001) Oral Oncol. 37, 65-71. 6.Vega, S. et al. (2004) Genes Dev. 18, 1131-1143. 7.Zhou, B.P. et al. (2004) Nat. Cell Biol. 6, 931-940. 8.Bachelder, R.E. et al. (2005) J. Cell Biol. 168, 29-33. 9.Yook, J.I. et al. (2005) J. Biol. Chem. 280, 11740-11748. 10.Yang, Z. et al. (2005) Cancer Res. 65, 3179-3184.