SOCS1 (E4K7Q) Rabbit mAb

The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway (1-3). The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein (CIS1), as well as SOCS1-7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. These proteins are important regulators of cytokine signaling, proliferation, differentiation, and immune responses.SOCS1 (suppressor of cytokine signaling 1), also known as JAB (Janus Kinase binding protein), SSI-1 (Stat-induced Stat inhibitor-1), and TIP3 (Tec-interacting protein 3) (4-7), is a cytokine-regulated SOCS family member that directly inhibits Jak family members through interaction within their kinase activation loop. In addition to inhibiting Jak/Stat signaling, SOCS1 can also negatively regulate Toll-like receptors that contribute to innate immunity (8,9). The SOCS box of SOCS1 can trigger ubiquitin-mediated degradation of proteins within and outside of the Jak/Stat pathway (10,11). The highest expression of SOCS1 is seen in the thymus and spleen and it plays a critical role in T cell activation and lymphocyte differentiation (4,12). SOCS1 also functions as a tumor suppressor protein by inhibiting hematopoietic oncogenes (13,14). 1.Alexander, W.S. et al. (1999) J Leukoc Biol 66, 588-92. 2.Chen, X.P. et al. (2000) Immunity 13, 287-90. 3.Hilton, D.J. et al. (1998) Proc Natl Acad Sci USA 95, 114-9. 4.Starr, R. et al. (1997) Nature 387, 917-21. 5.Endo, T.A. et al. (1997) Nature 387, 921-4. 6.Naka, T. et al. (1997) Nature 387, 924-9. 7.Ohya, K.i. et al. (1997) J Biol Chem 272, 27178-82. 8.Kinjyo, I. et al. (2002) Immunity 17, 583-91. 9.Davey, G.M. et al. (2006) Tissue Antigens 67, 1-9. 10.Kamizono, S. et al. (2001) J Biol Chem 276, 12530-8. 11.Rui, L. et al. (2002) J Biol Chem 277, 42394-8. 12.Marine, J.C. et al. (1999) Cell 98, 609-16. 13.De Sepulveda, P. et al. (1999) EMBO J 18, 904-15. 14.Rottapel, R. et al. (2002) Oncogene 21, 4351-62.