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产品介绍
产品介绍
产品信息
商品描述
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
分子量
246.35
纯度
98%
可溶性
DMSO:49 mg/mL (198.9 mM)
In vitro(体外研究)
Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM.
In vivo(体内研究)
Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94mg/kg (i.v.)
背景
分子式
C15H22N2O
CAS号
6483-15-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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