Mouse Monoclonal SOX10 Antibody (SPM607) - IHC-Prediluted

Protein A or G purified

Mouse

Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag (Uniprot: P56693)

The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.

IgG2b Kappa

Monoclonal

Protein A or G purified

0.05% Sodium Azide

Monoclonal

SOX10

Immunohistochemistry Immunohistochemistry-Paraffin

HuSpecies Glossary

Recognizes a protein of ~55kDa, identified as SOX10. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.