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产品信息
商品描述
Sp-cAMPS, a stimulatory diastereoisomer of adenosine 3‘,5‘-(cyclic)phosphorothioate, has been shown to contain an axial exocyclic sulphur atom. Experiments have noted that this agent binds to holoenzymes, releases its catalytic subunit and activates phosphotransferase and cAMP-dependent protein kinase activity. Additionally, Sp-cAMPS has demonstrated the ability to mimick glucagon-stimulated increases in the level of Ca2+ in hepatocytes.
分子量
446.5
纯度
≥98%
可溶性
Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)
应用
实验应用
An activator of phosphotransferase and cAMP-dependent kinase
背景
分子式
C10H11N5O5PS·C6H16N
CAS号
93602-66-5
沸点
641.7° C at 760 mmHg (Predicted)
MDL
MFCD01459901
PK值
pKa: 1 (Predicted), pKb: 3.63 (Predicted)
光学活性
α22/D -25.43°, c = 0.99 in water(lit.)
制备和贮存
保存方式
Store at -20° C
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