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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated

纯化方式
Protein A

宿主
Rabbit

同种型
IgG

克隆号
S-R346

浓度
0.5 mg/ml

性状
Liquid

缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型
Recombinant mAb

应用
实验应用
WB、IHC-P、ICC、ICFCM

反应种属
Hu、Ms、Rt

稀释度
WB
1:1000IHC-P
1:2000ICC
1:500ICFCM
1:500
背景
别名
Sequestosome-1, EBI3-associated protein of 60 kDa (EBIAP, p60), Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, ORCA, OSIL

背景
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype. Mutations in SQSTM1 are a common cause of Paget's disease of bone.

细胞定位
Cytoplasm

制备和贮存
保存方式
12 months from date of receipt / reconstitution, -20 °C as supplied
数据库链接
Accession
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