p-Stat1 (pY701.4A)

鼠

p-Stat1抗体(pY701.4A)是小鼠单克隆IgG2a κ, 在21篇文献中引用，规格为200 µg/mlraised against a short amino acid sequence containing phosphorylated Tyr 701 of Stat1 of human origin推荐用于 mouse, rat 和 human 来源的Tyr 701 phosphorylated Stat1α and Stat1β WB, IP 和 IF检测关于如何获取p-Stat1 (pY701.4A): sc-136229的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。m-IgG Fc BP-HRP and m-IgG2a BP-HRP 是 p-Stat1 Antibody (pY701.4A) for WB首选应用二抗。这些试剂现在以套装形式提供p-Stat1 Antibody (pY701.4A) (见下方订购信息). 查看产品引用文献(21) Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Mouse, rat and human Stat1 are phosphorylated on tyrosine and serine residues, specifically Tyr 701 which is phosphorylated by JAK1, which promotes dimerization, allowing Stat1 to be translocated to the nucleus.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Replacement monoclonal antibody for: sc-7988, sc-135648, sc-7988-R.

磷酸化信号转导与转录激活因子1抗体,磷酸盐缓冲液

MouseStat1

6772;20846