p-Stat4 (pY693.38)

mouse

p-Stat4抗体(pY693.38)是小鼠单克隆IgG2b (kappa轻链)，规格为50 µg/500 µl raised against a short amino acid sequence containing phosphorylated Tyr 693 of Stat4 of human origin recommended for detection of Tyr 693 phosphorylated Stat4 of mouse, rat and human origin by WB 目前，我们还没有完成p-Stat4 抗体 (pY693.38)的首选二抗检测试剂的鉴定。这项工作正在进行中。 Membrane receptor signaling by various ligands, including interferons and growth hormones, induces activation of Jak kinases, which then leads to tyrosine phosphorylation of the Stat transcription factors. Upon activation by tyrosine phosphorylation, Stat proteins dimerize, translocate to the nucleus and bind to specific regulatory elements that control gene expression. Stat4 is most highly expressed in testis and myeloid cells and is an important element in mediating IL-12 signals. IL-12 induces sustained activation and nuclear translocation of Stat4, a process coupled to both tyrosine and serine phosphorylation of Stat4. Phosphorylation of Ser 721 of Stat4 is MEK-, ERK- and JNK-independent and p38-dependent, and is necessary for the transcriptional activity of Stat4.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Replacement monoclonal antibody for: sc-101804.

IGG-免疫球蛋白G型抗体

MouseStat4

6775;20849