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产品介绍
产品介绍
产品信息
抗原名称
STAT
商品描述
Stattic是STAT3的有效抑制剂，主要用于癌症的治疗。
分子量
211.19
纯度
＞98%
可溶性
DMSO : 10.6 mg/mL (50 mM)
Ethanol ： 1.1 mg/mL (5 mM)
Ethanol ： 1.1 mg/mL (5 mM)
外观
white to beige powder
In vitro(体外研究)
Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines. Stattic (2.5, 5, 10 μM; for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM; for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner.
In vivo(体内研究)
Stattic (10 mg/kg; i.p.; three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice.
背景
分子式
C8H5NO4S
CAS号
19983-44-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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