Novel focused OCT-LIF endoscope
文献求助- Biomed Opt Express
- 2011
- 2.9
- 2011 Jan 31;2(3):421-30.
- 10.1364/BOE.2.000421
- 信号转导
- (120.3890) Medical optics instrumentation; (170.2150) Endoscopic imaging; (170.2680) Gastrointestinal; (170.4500) Optical coherence tomography; (170.6280) Spectroscopy, fluorescence, and luminescence.
Abstract
Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.
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