EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process
文献求助- ASN Neuro
- 2022
- 3.9
- 2022 Jan-Dec:14:17590914221116574.
- 10.1177/17590914221116574
- 信号转导
- Bergmann glia; glutamate transporters; transcriptional control.
Abstract
EAAT1/GLAST down-regulates its expression and function at the transcriptional level by activating a signaling pathway that includes PI3K, PKC and NF-κB, favoring the notion of an activity-dependent fine-tuning of glutamate recycling and its synaptic transactions through glial cells.
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