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产品介绍
产品介绍
产品信息
抗原名称
VEGFR2；FGFR1；PDGFRβ
商品描述
SU 5402是VEGFR2和FGFR1的多靶点抑制剂，IC50分别为20和30 nM。
分子量
296.32
纯度
>98%
可溶性
DMSO ：29.6 mg/mL (100 mM)
外观
light orange to dark orange powder
In vitro(体外研究)
SU5402 inhibits VEGF-, FGF-, PDGF- dependent cell proliferation with IC50 of 0.05 μM, 2.80μM, 28.4 μM, respectively. In HUVECs, SU5416 selectively inhibits VEGF-driven mitogenesis in a dose-dependent manner with IC50 of 0.04 μM. In nasopharyngeal epithelial cells, SU5402 attenuates LMP1-mediated aerobic glycolysis, cellular transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 diminishes the effect of FGF23 on cell differentiation.
In vivo(体内研究)
In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.
背景
分子式
C17H16N2O3
CAS号
215543-92-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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