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SW-100
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产品介绍
产品介绍
产品信息
抗原名称
HDAC1；HDAC2；HDAC3；HDAC4；HDAC5；HDAC6；HDAC7
商品描述
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.
分子量
316.78
纯度
98%
可溶性
DMSO : ≥ 125 mg/mL (394.60 mM)
In vitro(体外研究)
SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.Western Blot AnalysisCell Line:HEK293 cellsConcentration:0.01, 0.1, 1, 10 µM Incubation Time:48 hoursResult:Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.
In vivo(体内研究)
SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome.
背景
分子式
C17H17ClN2O2
CAS号
2126744-35-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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