Synaptophysin (D8F6H) Rabbit mAb

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). 1.Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. 2.Valtorta, F. et al. (2004) Bioessays 26, 445-53. 3.Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. 4.Bonanomi, D. et al. (2007) Biochem J 404, 525-34.