TACE (CT), ADAM 17 (CT), (TNFa Converting Enz)

Antigen Immunoaffiinity Purification

disintegrin and metalloproteinase domain-containing protein 17 preproprotein

Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.

Tumor-necrosis factor- is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF- is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-. TNF- converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately (1-3). TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGF, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. (6)

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Polyclonal

Western Blot (WB)

Human, Mouse, Rat

TNF- Converting Enzyme C-terminal; ADAM17; CSVP; TACE

6868

P78536 [Other Products]