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产品介绍
产品信息
荧光素标记
抗原名称
TDP43
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala260 of human TDP43. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
45
研究领域
神经科学
应用
反应种属
Human,Mouse,Rat,
目标/特异性
Specificity/Sensitivity
TDP43 (A260) Antibody detects endogenous levels of total TDP43 protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
TDP43 (TAR DNA-binding protein 43) is involved in transcriptional regulation and exon splicing (1,2). While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In these disorders, TDP43 is abnormally ubiquitinated, phosphorylated, and cleaved to generate carboxy-terminal fragments that are sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites (3,4). Additionally, TDP43 inhibits the expression of the HIV-1 gene and regulates CFTR gene splicing (1,5).
1.Ou, S.H. et al. (1995) J Virol 69, 3584-96.
2.Winton, M.J. et al. (2008) J Biol Chem 283, 13302-9.
3.Neumann, M. et al. (2006) Science 314, 130-3.
4.Cairns, N.J. et al. (2007) Am J Pathol 171, 227-40.
5.Buratti, E. and Baralle, F.E. (2001) J Biol Chem 276, 36337-43.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
23435
UniProt ID
Q13148
参考图片
Western blot analysis of extracts from HeLa cells and rat brain using TDP43 (A260) Antibody.
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