Phospho-TBK1/NAK (Ser172) (D52C2) Rabbit mAb

TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).TBK1 is phosphorylated at Ser172 within its activation loop, which is necessary for its kinase activity including the downstream phosphorylation of IRF3 (4,5). 1.Tojima, Y. et al. (2000) Nature 404, 778-82. 2.Pomerantz, J.L. and Baltimore, D. (1999) EMBO J 18, 6694-704. 3.Fitzgerald, K.A. et al. (2003) Nat Immunol 4, 491-6. 4.Kishore, N. et al. (2002) J Biol Chem 277, 13840-7. 5.McCoy, C.E. et al. (2008) J Biol Chem 283, 14277-85.