TC-S 7005 (10 mg)

24971422

Potent and selective PLK2 inhibitor

359.38

3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine

Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC₅₀ = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC₅₀ values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

≥98% (HPLC)

Soluble to 100 mM in DMSO

C[C@H](NC2=CC(C(C4=CC=C(OCO5)C5=C4)=NO3)=C3C=N2)C1=CC=CC=C1

C₂₁H₁₇N₃O₃

1082739-92-1