TCS 2314 (10 mg)

11226207

α₄β₁ (VLA-4) antagonist

522.59

1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid

Integrin very late antigen-4 (VLA-4; α₄β₁) antagonist (IC₅₀ = 4.4 nM). Blocks the activation of inflammatory cells.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 50 mM in ethanol

O=C(N2CCOC[C@H]2[C@@](N3CCC(CC(O)=O)CC3)=O)CC1=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C1

C₂₈H₃₄N₄O₆

317353-73-4