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TD-165
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产品介绍
产品介绍
产品信息
抗原名称
cereblon:20.4 nM (DC50)
商品描述
TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group[1].
分子量
870.07
纯度
98%
可溶性
DMSO:40 mg/mL (110.38 mM)
In vitro(体外研究)
Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells[1]. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%[1].
背景
分子式
C46H59N7O8S
CAS号
2305936-56-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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