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TDZD-8
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产品介绍
产品介绍
产品信息
抗原名称
GSK-3
商品描述
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.
分子量
222.26
纯度
>98%
可溶性
DMSO ：44.5 mg/mL (200.21 mM)；
Ethanol ：44.5 mg/mL (200.21 mM)
Ethanol ：44.5 mg/mL (200.21 mM)
外观
White to off white powder
In vitro(体外研究)
TDZD8 results in a significant decline of cellular ATP levels in PC-3 cells. TDZD8 (10 μM) treatment also triggers a drastic autophagy response and AMPK activation in PC-3 cells. Furthermore, TDZD8 (10 μM) reduces mTOR phosphorylation levels at the S2448 site. In addition, TDZD8 (10 μM) induces LKB1 nuclear-cytoplasm translocation.
In vivo(体内研究)
TDZD-8 (TDZD8, 1 or 2 mg/kg, i.p.) both reduces the induction of p-DARPP32 following chronic L-dopa treatment in parkinsonian animals. TDZD8 treatment of 21 days induces a significant reduction in PKA expression in rats with established dyskinesia. Moreover, TDZD8 reduces FosB mRNA level in the striatum and lowers the expression of PPEB mRNA to similar levels as in 6-OHDA-lesioned rats without treated with L-dopa. The decrease in dyskinesia induced by TDZD8 is overcome by dopamine rceptor-1 agonist.
背景
别名
TDZD8； TDZD 8；GSK-3β Inhibitor I； NP 01139
分子式
C10H10N2O2S
CAS号
327036-89-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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