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产品介绍
产品介绍
产品信息
商品描述
Temocaprilat is an antihypertensive and the active metabolite of temocapril. This compound inhibits ACE (angiotensin-converting enzyme), which catalyzes the conversion of angiotensin I to angiotensin II by cleaving a dipeptide from the C-terminus. Angiotensin II binds to angiotensin II receptors, causing vasoconstriction and an increase in bloodpressure. Furthermore, the binding of angiotensin II causes the release of aldosterone, which causes reabsorption of water and sodium in the distal tubule.
分子量
448.56
可溶性
Soluble in DMSO.
IC50
Angiotensin-converting enzyme: IC50 = 3.6 nM (European rabbit)
Ki 数据
Canalicular multispecific organic anion transporter 1: Ki= 343 µM (rat)
应用
实验应用
An ACE inhibitor and active metabolite of temocapril
背景
别名
[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮杂卓-4-基]乙酸
分子式
C21H24N2O5S2
CAS号
110221-53-9
沸点
~743.6° C at 760 mmHg (Predicted)
MDL
MFCD00871951
PK值
pKa: 2.09 (Predicted), pKb: 7.49 (Predicted)
密度
~1.4 g/cm3 (Predicted)
折射率
n20D 1.67 (Predicted)
光学活性
α20/D 63.4º, c = 1 in DMF
制备和贮存
保存方式
Store at -20° C
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