GTF2H2 (HRP)

HRP

Recombinant protein corresponding to aa1-157 from human general transcription factor IIH subunit 2 protein.

Suitable for use in ELISA. Other applications not tested.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminal of GTF2H2 interacts with and regulates XPD whereas an intact C-terminal is required for a successful escape of RNAP II form the promoter.

IgG

Polyclonal

Purified by Protein G affinity chromatography.

Suitable for use in ELISA. Other applications not tested.

Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Recognizes human GTF2H2.

General transcription factor IIH subunit 2 (Basic transcription factor 2 44kD subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit), GTF2H2, BTF2P44

Q13888