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产品介绍
产品介绍
产品信息
商品描述
TGF-β RI Kinase Inhibitor III is a cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of ACTR-IB (activin receptor-like kinase 4, IC50 = 129 nM), TGF β RI (activin receptor-like kinase 5, IC50 = 47 nM), and ACTR-IC (activin receptor-like kinase 7). TGF-β RI Kinase Inhibitor III inhibits p38 MAPKα only at much higher concentrations IC50 = 10.6 βM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
分子量
371.9
纯度
≥97%
可溶性
Soluble in DMSO (20 mg/ml), and water (3 mg/ml).
IC50
Activin receptor-like kinase 4: IC50 = 129 nM; Activin receptor-like kinase 5: IC50 = 47 nM; p38 MAPKα : IC50 = 10.6 µM
应用
实验应用
An inhibitor of activin receptor-like kinase 4
背景
分子式
C20H21N3O2 HCl
CAS号
356559-13-2
沸点
532.7° C at 760 mmHg (Predicted)
制备和贮存
保存方式
Store at 4° C
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