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>95% by SDS-PAGE
Transforming growth factor alpha (TGF-α), a polypeptide of 5.5kDa that is partially homologous to epidermal growth factor (EGF), is important in the control of glial and Schwann cell proliferation and survival of differentiated neurons. TGF-α is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF-β to promote anchorage-independent cell proliferation in soft agar. Although TGF-α commonly acts via autocrine or paracrine signaling in solid tissues, it can also mediate paracrine signaling by activated macrophages, monocytes, neutrophils, and eosinophils.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
参考图片
Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells, The EC50 for this effect is less than 0.6ng/ml.
1μg (R: reducing conditions, N: non-reducing conditions).