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产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
CTMP
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues of human CTMP. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
分子量
22, 26
研究领域
癌症,代谢,神经科学
应用
反应种属
Human,Mouse,Rat,
目标/特异性
Specificity/Sensitivity
CTMP Antibody detects endogenous levels of total CTMP protein.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Carboxyl-terminal modulator protein (CTMP) is a negative regulator of Akt and was identified as an Akt binding protein. Akt, also referred to as PKB or Rac, plays a critical role in controlling the balance between survival and apoptosis (1-3). This protein kinase, activated by insulin and various growth and survival factors, functions in a wortmannin-sensitive pathway involving PI3 kinase (2,3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4), and by phosphorylation within the carboxy-terminus at Ser473. CTMP binds to the regulatory domain of Akt at the carboxy terminus of the protein and inhibits phosphorylation on Thr308 and Ser473 (5).
1.Franke , T. F. et al. (1997) Cell 88, 435-437.
2.Burgering, B.M. and Coffer, P.J. (1995) Nature 376, 599-602.
3.Franke, . F. et al. (1995) Cell 81, 727-736.
4.Alessi, D. R. et al. (1996) EMBO J. 15, 6541-6551.
5.Maira, S. M. et al. (2001) Science 294, 374-380.
研究领域
癌症,代谢,神经科学
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
117145
UniProt ID
Q5T1C6
参考图片
Western blot analysis of extracts from HeLa, NIH/3T3 and C6 cells, using the CTMP Antibody.
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