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Thyroid Hormone Receptor Antagonist, 1-850
品牌： Absin
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对比
咨询分子式：
C21H20F3N5O4
分子量：
463.42
产品介绍
产品介绍
产品信息
商品描述
Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which acts as a selective and high-affinity thyroid receptor antagonist (IC50 = 1.5 μM in HeLa cells). It is shown to block T3- (L-triiodothyronine) mediated interaction of TRα with nuclear receptor coactivator (NRC) as well as prevent the stimulation of gene expression. It exerts no effect on the retinoic acid receptor α (RARα) activity.
分子量
463.42
纯度
≥98%
可溶性
Soluble in DMSO (5 mg/ml).
应用
实验应用
A selective and high-affinity thyroid hormone receptor (TR) antagonist
背景
别名
TR Antagonist; 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
分子式
C21H20F3N5O4
CAS号
251310-57-3
MDL
MFCD06411459
制备和贮存
保存方式
Store at-20℃，3 years.
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