TIGIT

Extracellular domain of human TIGIT.

Suitable for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.

The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

IgG1

4A12

Monoclonal

Purified by Protein A affinity chromatography.

Suitable for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.

Immunohistochemistry (paraffin): 2ug/ml Immunofluorescence: 1ug/ml Flow Cytometry: 1ug/ml Immunocytochemistry: 1ug/ml Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher.

Mouse

Hu

Recognizes human TIGIT.

TIGIT: T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM

201633

Q495A1