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TMCB
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产品介绍
产品介绍
产品信息
商品描述
TMCB has been shown to inhibit both casein kinase 2 (CK2) and MAPK15 (ERK8/extracellular-signal-regulated kinase 8) (IC50 = 0.50 μM for both CK2 and ERK8). In studies, TMCB has shown selectivity for CK2 over protein kinases which are normally affected by the casein kinase 2 inhibitors.
分子量
534.82
可溶性
Soluble in DMSO (25 mM).
外观
White solid
IC50
CK2: IC50 = 0.5 µM; ERK8: IC50 = 0.5 µM
Ki 数据
casein kinase IIα: Ki= 21 nM (human); CK2: Ki= 0.25 µM; PIM1: Ki= 8.65 µM; DYRK1a: Ki= 11.90 µM; HIPK2: Ki= 15.25 µM
背景
别名
ERK8 Inhibitor I; Casein Kinase II Inhibitor VI
分子式
C11H9Br4N3O2
CAS号
905105-89-7
PK值
pKb: 3.43 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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