TMEM119 (E4B9S) Mouse mAb

Transmembrane protein 119 (TMEM119) is a cell-surface protein of unknown function, expressed exclusively by the microglia subset of myeloid and neural cells (1). Iba1+ microglia with both ramified and amoeboid morphologies express TMEM119, while Iba1+ macrophages are TMEM119 negative (2). TMEM119 and other homeostatic genes have been shown to be downregulated in disease-associated microglia (DAM). These DAM microglia are conserved in human and mouse and have been identified in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and 5XFAD and APP/PS1 mouse models (3,4). This protein’s specificity as a microglia marker has proven itself important for labeling microglia in healthy tissue as well as deciphering them from infiltrating macrophages and other cells types in neurodegenerative disease models (1,2). 1.Bennett, M.L. et al. (2016) Proc Natl Acad Sci U S A 113, E1738-46. 2.Satoh, J. et al. (2016) Neuropathology 36, 39-49. 3.Deczkowska, A. et al. (2018) Cell 173, 1073-81. 4.Keren-Shaul, H. et al. (2017) Cell 169, 1276-1290.e17.